Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC Apixaban 503612-47-3 200mg
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Apixaban (CAS 503612-47-3) is a highly selective reversible inhibitor of coagulation Factor Xa with Ki values of 0 08 nM and 0 17 nM for human and rabbit enzymes respectively By targeting Factor Xa a central serine protease in the coagulation cascade apixaban effectively impedes thrombin generation and subsequent clot formation In vitro apixaban prolongs coagulation parameters in human plasma at submicromolar concentrations and demonstrates potent antithrombotic activity across multiple animal models With favorable pharmacokinetics including high oral bioavailability and low clearance in preclinical studies apixaban serves as a valuable tool for investigating coagulation mechanisms and evaluating anticoagulant strategies
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TARGETMOL CHEMICALS INC MQAE 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. MQAE, a fluorescent chloride ion indicator, is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells. MQAE is quenched via collision with chloride.
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Apexbio Technology LLC Dihydrexidine hydrochloride 158704-02-0 5mg
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Dihydrexidine hydrochloride is a small-molecule agonist targeting the dopamine D1 receptor It is designed to selectively activate the D1 receptor subtype thereby modulating cyclic AMP-mediated signal transduction pathways Dihydrexidine hydrochloride exerts its biological activity primarily through dopaminergic D1 receptor stimulation It demonstrates receptor activation with an EC50 value of approximately 72 21 nM Based on these pharmacological properties dihydrexidine hydrochloride holds research potential in investigating dopaminergic neurotransmission mechanisms and evaluating dopamine receptor involvement in neural function as well as in biological screening assays for receptor-mediated functional effects in neuronal models
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Medchemexpress LLC Pyrroloquinoline quinone disodium salt | 122628-50-6 | 98.0% | 374.17 g/mol | C14H4N2Na2O8 | 50 MG
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Pyrroloquinoline quinone disodium salt is the disodium salt form of the redox cofactor PQQ supplied for research and analytical applications. The material is a pink to red solid used in studies of metabolism, oxidative stress, and cellular signaling. It is provided as a small powdered reagent with recommended sealed storage to preserve stability.
- Redox co-factor used in metabolic and oxidative stress research.
- High purity suitable for analytical and biological applications.
- Pink to red solid that is easy to weigh and handle.
- Stable when stored sealed and protected from moisture.
- Available in small powder pack sizes for laboratory use.
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Medchemexpress LLC TNF-α (31-45), human | 144796-71-4 | 99.99% | 1667.87 | 5 MG
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TNF-α (31-45), human is a potent NF-kB pathway activator and a proinflammatory cytokine that induces necrosis or apoptosis. It stimulates the NF-κB pathway via TNFR2, promoting cancer growth, invasion, and metastasis.
- Potent NF-κB pathway activator
- Induces necrosis or apoptosis
- Stimulates NF-κB pathway via TNFR2
- Promotes cancer growth, invasion, and metastasis
- High purity (99.99% by HPLC)
- Molecular weight of 1667.87
- White to off-white solid appearance
- Sequence: Arg-Arg-Ala-Asn-Ala-Leu-Leu-Ala-Asn-Gly-Val-Glu-Leu-Arg-Asp
- Soluble in water at 50 mg/mL (requires ultrasonic)
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eMolecules 6-FLUORO-2-METHYLQUINOLINE 5G
5000215949 6-FLUORO-2-METHYLQUINOLINE 5G
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Medchemexpress LLC Abiraterone | 154229-19-3 | 99.8% | 200 MG
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Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity. It inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17. It is for research use only.
- Potent and irreversible CYP17A1 inhibitor
- Exhibits antiandrogen activity
- Inhibits 17α-hydroxylase with IC50 of 2.5 nM
- Inhibits 17,20-lyase activity with IC50 of 15 nM
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Selleck Chemical LLC STF-31
STF-31 is a selective glucose transporter GLUT1 inhibitor
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000369287 HJC0350 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000597130 GUANIDINOETHYL SULFO 500MG
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Medchemexpress LLC Firmonertinib mesylate | 2130958-55-1 | 100.0% | 664.70 | 50 MG
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Firmonertinib mesylate is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It inhibits EGFR active mutations as well as the T790M acquired resistant mutation. It has potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations and T790M acquired resistant mutation
- Potential for research of cancer diseases, especially advanced NSCLC with EGFR ex20ins mutation
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eMolecules N2-FMOC-N6- ALLYLOXYCARBO 1G
5000162166 N2-FMOC-N6- ALLYLOXYCARBO 1G
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Chemscene CHEMSCENE
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5000580145 RESIQUIMOD 1G
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Medchemexpress LLC Diflucortolone valerate | 59198-70-8 | 478.57 | 200 MG
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Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases. It is a potent corticosteroid esterified with valeric acid, which helps reduce swelling, itching, and redness. It is for research use only and not sold to patients. The product appears as a white to off-white solid.
- Powerful corticosteroid
- Used for research of various skin diseases
- Esterified with valeric acid
- Helps reduce swelling, itching, and redness
- Appears as a white to off-white solid
- For research use only
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Apexbio Technology LLC NSC 74859 501919-59-1 200mg
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NSC 74859 (CAS 501919-59-1) also known as S3I-201 is a selective inhibitor of the signal transducer and activator of transcription 3 (Stat3) pathway S3I-201 disrupts Stat3 DNA-binding activity exhibiting an IC50 of 86 M in vitro with minimal inhibitory effects on Stat1 and Stat5 It also impedes the formation of Stat1-Stat3 and Stat1-Stat1 complexes with IC50 values of 160 M and 300 M respectively In NIH 3T3/v-Src fibroblasts S3I-201 reduces constitutive Stat3 activation and pTyr-705 Stat3 levels induces apoptosis at 30 100 M and downregulates cyclin D1 Bcl-xL and survivin expression This compound is widely utilized in research to interrogate Stat3 function in cellular transformation and oncogenic signaling pathways
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